Mitochondrial Lon-induced mtDNA leakage contributes to PD-L1–mediated immunoescape via STING-IFN signaling and extracellular vesicles

BACKGROUND: Mitochondrial Lon is a chaperone and DNA-binding protein that functions in protein quality control and stress response pathways. The level of Lon regulates mitochondrial DNA (mtDNA) metabolism and the production of mitochondrial reactive oxygen species (ROS). However, there is little inf...

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Detalles Bibliográficos
Autores principales: Cheng, An Ning, Cheng, Li-Chun, Kuo, Cheng-Liang, Lo, Yu Kang, Chou, Han-Yu, Chen, Chung-Hsing, Wang, Yi-Hao, Chuang, Tsung-Hsien, Cheng, Shih-Jung, Lee, Alan Yueh-Luen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Immunotherapy Biomarkers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7713199/
https://www.ncbi.nlm.nih.gov/pubmed/33268351
http://dx.doi.org/10.1136/jitc-2020-001372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7713199/
https://www.ncbi.nlm.nih.gov/pubmed/33268351
http://dx.doi.org/10.1136/jitc-2020-001372

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