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Local environment effects on charged mutations for developing aggregation-resistant monoclonal antibodies
Protein aggregation is a major concern in biotherapeutic applications of monoclonal antibodies. Introducing charged mutations is among the promising strategies to improve aggregation resistance. However, the impact of such mutations on solubilizing activity depends largely on the inserting location,...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7713239/ https://www.ncbi.nlm.nih.gov/pubmed/33273506 http://dx.doi.org/10.1038/s41598-020-78136-1 |