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The intracellular lipid-binding domain of human Na(+)/H(+) exchanger 1 forms a lipid-protein co-structure essential for activity

Dynamic interactions of proteins with lipid membranes are essential regulatory events in biology, but remain rudimentarily understood and particularly overlooked in membrane proteins. The ubiquitously expressed membrane protein Na(+)/H(+)-exchanger 1 (NHE1) regulates intracellular pH (pH(i)) with dy...

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Detalles Bibliográficos
Autores principales: Hendus-Altenburger, Ruth, Vogensen, Jens, Pedersen, Emilie Skotte, Luchini, Alessandra, Araya-Secchi, Raul, Bendsoe, Anne H., Prasad, Nanditha Shyam, Prestel, Andreas, Cardenas, Marité, Pedraz-Cuesta, Elena, Arleth, Lise, Pedersen, Stine F., Kragelund, Birthe B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7713384/
https://www.ncbi.nlm.nih.gov/pubmed/33273619
http://dx.doi.org/10.1038/s42003-020-01455-6