Cargando…
The intracellular lipid-binding domain of human Na(+)/H(+) exchanger 1 forms a lipid-protein co-structure essential for activity
Dynamic interactions of proteins with lipid membranes are essential regulatory events in biology, but remain rudimentarily understood and particularly overlooked in membrane proteins. The ubiquitously expressed membrane protein Na(+)/H(+)-exchanger 1 (NHE1) regulates intracellular pH (pH(i)) with dy...
Autores principales: | Hendus-Altenburger, Ruth, Vogensen, Jens, Pedersen, Emilie Skotte, Luchini, Alessandra, Araya-Secchi, Raul, Bendsoe, Anne H., Prasad, Nanditha Shyam, Prestel, Andreas, Cardenas, Marité, Pedraz-Cuesta, Elena, Arleth, Lise, Pedersen, Stine F., Kragelund, Birthe B. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7713384/ https://www.ncbi.nlm.nih.gov/pubmed/33273619 http://dx.doi.org/10.1038/s42003-020-01455-6 |
Ejemplares similares
-
Molecular basis for the binding and selective dephosphorylation of Na(+)/H(+) exchanger 1 by calcineurin
por: Hendus-Altenburger, Ruth, et al.
Publicado: (2019) -
The human Na(+)/H(+) exchanger 1 is a membrane scaffold protein for extracellular signal-regulated kinase 2
por: Hendus-Altenburger, Ruth, et al.
Publicado: (2016) -
The prolactin receptor scaffolds Janus kinase 2 via co-structure formation with phosphoinositide-4,5-bisphosphate
por: Araya-Secchi, Raul, et al.
Publicado: (2023) -
Dark peptide discs for the investigation of membrane proteins in supported lipid bilayers: the case of synaptobrevin 2 (VAMP2)
por: Luchini, Alessandra, et al.
Publicado: (2022) -
Dynamic Na(+)/H(+) exchanger 1 (NHE1) – calmodulin complexes of varying stoichiometry and structure regulate Ca(2+)-dependent NHE1 activation
por: Sjøgaard-Frich, Lise M, et al.
Publicado: (2021)