Effect of escitalopram on Aβ levels and plaque load in an Alzheimer mouse model

BACKGROUND: Several neurotransmitter receptors activate signaling pathways that alter processing of the amyloid precursor protein (APP) into β-amyloid (Aβ). Serotonin signaling through a subset of serotonin receptors suppresses Aβ generation. We proposed that escitalopram, the most specific selectiv...

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Detalles Bibliográficos
Autores principales: Cirrito, John R., Wallace, Clare E., Yan, Ping, Davis, Todd A., Gardiner, Woodrow D., Doherty, Brookelyn M., King, Diana, Yuede, Carla M., Lee, Jin-Moo, Sheline, Yvette I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7713734/
https://www.ncbi.nlm.nih.gov/pubmed/32913022
http://dx.doi.org/10.1212/WNL.0000000000010733

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7713734/
https://www.ncbi.nlm.nih.gov/pubmed/32913022
http://dx.doi.org/10.1212/WNL.0000000000010733

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