Cargando…

SHP2 knockdown ameliorates liver insulin resistance by activating IRS‐2 phosphorylation through the AKT and ERK1/2 signaling pathways

Diabetes is a chronic metabolic disease characterized by insulin resistance (IR). SHP2 has previously been identified as a potential target to reduce IR in diabetes. Here, we examined the effects of SHP2 on glucose consumption (GC), IR level and the expression of insulin receptor substrate (IRS), AK...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yue, Xinxin, Han, Tao, Hao, Wei, Wang, Min, Fu, Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7714075/ https://www.ncbi.nlm.nih.gov/pubmed/33012117 http://dx.doi.org/10.1002/2211-5463.12992

Ejemplares similares

Shp2 Knockdown and Noonan/LEOPARD Mutant Shp2–Induced Gastrulation Defects
por: Jopling, Chris, et al.
Publicado: (2007)

Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling
por: Choi, Eunhee, et al.
Publicado: (2019)

SHP-2 Promotes the Maturation of Oligodendrocyte Precursor Cells Through Akt and ERK1/2 Signaling In Vitro
por: Liu, Xiujie, et al.
Publicado: (2011)

Impact of SHP2 tyrosine phosphorylation on the development of acquired resistance to allosteric SHP2 inhibitors
por: Franciosa, Giulia, et al.
Publicado: (2023)

Grb2 binding induces phosphorylation-independent activation of Shp2
por: Lin, Chi-Chuan, et al.
Publicado: (2021)

Shp2 SUMOylation promotes ERK activation and hepatocellular carcinoma development
por: Deng, Rong, et al.
Publicado: (2015)

Phosphorylation of insulin receptor substrates (IRS-1 and IRS-2) is attenuated following cecal ligation and puncture in mice
por: Mathew, Deepa, et al.
Publicado: (2023)

Phosphorylation of SHP2 at Tyr62 Enables Acquired Resistance to SHP2 Allosteric Inhibitors in FLT3-ITD–Driven AML
por: Pfeiffer, Anamarija, et al.
Publicado: (2022)

Y772 phosphorylation of EphA2 is responsible for EphA2-dependent NPC nasopharyngeal carcinoma growth by Shp2/Erk-1/2 signaling pathway
por: Xiang, Yi-Ping, et al.
Publicado: (2020)

Alpinia officinarum Rhizome ameliorates the UVB induced photoaging through attenuating the phosphorylation of AKT and ERK
por: Jung, Jong Min, et al.
Publicado: (2022)

Identification of linderalactone as a natural inhibitor of SHP2 to ameliorate CCl(4)-induced liver fibrosis
por: Zhang, Yi, et al.
Publicado: (2023)

Targeting macrophagic SHP2 for ameliorating osteoarthritis via TLR signaling
por: Sun, Ziying, et al.
Publicado: (2022)

SHP2 Drives Adaptive Resistance to ERK Signaling Inhibition in Molecularly Defined Subsets of ERK-Dependent Tumors
por: Ahmed, Tamer A., et al.
Publicado: (2019)

Selective insulin resistance with differential expressions of IRS-1 and IRS-2 in human NAFLD livers
por: Honma, Midori, et al.
Publicado: (2018)

Therapeutic Suppression of FAK-AKT Signaling Overcomes Resistance to SHP2 Inhibition in Colorectal Carcinoma
por: Li, Ye, et al.
Publicado: (2021)

Carpachromene Ameliorates Insulin Resistance in HepG2 Cells via Modulating IR/IRS1/PI3k/Akt/GSK3/FoxO1 Pathway
por: Alaaeldin, Rania, et al.
Publicado: (2021)

Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity
por: Ahmed, Zamal, et al.
Publicado: (2013)

Triterpenoid Saponins from Stauntonia chinensis Ameliorate Insulin Resistance via the AMP-Activated Protein Kinase and IR/IRS-1/PI3K/Akt Pathways in Insulin-Resistant HepG2 Cells
por: Hu, Xin, et al.
Publicado: (2014)

Kinsenoside ameliorates intervertebral disc degeneration through the activation of AKT-ERK1/2-Nrf2 signaling pathway
por: Wang, Yanqiu, et al.
Publicado: (2019)

Liraglutide ameliorates nonalcoholic fatty liver disease in diabetic mice via the IRS2/PI3K/Akt signaling pathway
por: Yang, Pijian, et al.
Publicado: (2019)

Inhibition of Shp2 ameliorates monocrotaline-induced pulmonary arterial hypertension in rats
por: Cheng, Yusheng, et al.
Publicado: (2018)

The Tyrosine Phosphatase SHP2: A New Target for Insulin Resistance?
por: Saint-Laurent, Céline, et al.
Publicado: (2022)

Trilobatin ameliorates insulin resistance through IRS-AKT-GLUT4 signaling pathway in C2C12 myotubes and ob/ob mice
por: Liu, Min, et al.
Publicado: (2020)

Astragalus polysaccharide ameliorates insulin resistance in HepG2 cells through activating the STAT5/IGF‐1 pathway
por: Yue, Xinxin, et al.
Publicado: (2023)

Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells
por: Niogret, Charlène, et al.
Publicado: (2019)

SHP2 participates in decidualization by activating ERK to maintain normal nuclear localization of progesterone receptor
por: Chen, Lin, et al.
Publicado: (2023)

Epigallocatechin-3-gallate ameliorates LPS-induced inflammation by inhibiting the phosphorylation of Akt and ERK signaling molecules in rat H9c2 cells
por: Li, Zhi Hui, et al.
Publicado: (2020)

SUN-651 Murine Cecal Ligation and Puncture (CLP) Perturbs Phosphorylation of Insulin Receptor Substrate 2 (IRS-2)
por: Mathew, Deepa, et al.
Publicado: (2020)

Siglec-6 Signaling Uses Src Kinase Tyrosine Phosphorylation and SHP-2 Recruitment
por: Stefanski, Adrianne L., et al.
Publicado: (2022)

EZH2 Gene Knockdown Inhibits Sheep Pituitary Cell Proliferation via Downregulating the AKT/ERK Signaling Pathway
por: Cai, Yu, et al.
Publicado: (2023)

Selective inhibition of leukemia-associated SHP2(E69K) mutant by the allosteric SHP2 inhibitor SHP099
por: Sun, X, et al.
Publicado: (2018)

Suppression of protein kinase C theta contributes to enhanced myogenesis In vitro via IRS1 and ERK1/2 phosphorylation
por: Marino, Joseph S, et al.
Publicado: (2013)

RNF7 knockdown inhibits prostate cancer tumorigenesis by inactivation of ERK1/2 pathway
por: Xiao, Yangjiong, et al.
Publicado: (2017)

GITR/GITRL reverse signalling modulates the proliferation of hepatic progenitor cells by recruiting ANXA2 to phosphorylate ERK1/2 and Akt
por: He, Yu, et al.
Publicado: (2022)

A Novel PTP1B Inhibitor-Phosphate of Polymannuronic Acid Ameliorates Insulin Resistance by Regulating IRS-1/Akt Signaling
por: Li, Dan, et al.
Publicado: (2021)

Resveratrol metabolites ameliorate insulin resistance in HepG2 hepatocytes by modulating IRS-1/AMPK
por: Teng, Wendi, et al.
Publicado: (2018)

Phosphorylation of Akt and ERK1/2 Is Required for VEGF-A/VEGFR2-Induced Proliferation and Migration of Lymphatic Endothelium
por: Dellinger, Michael T., et al.
Publicado: (2011)

Functions of Shp2 in cancer
por: Zhang, Jie, et al.
Publicado: (2015)

Sidestepping SHP2 inhibition
por: Popescu, Bogdan, et al.
Publicado: (2023)

IRS-2 Partially Compensates for the Insulin Signal Defects in IRS-1(−/−) Mice Mediated by miR-33
por: Tang, Chen-Yi, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_8i8b5c5enmfvqun9lkrmr3ntn4