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Cyclin D3 Governs Clonal Expansion of Dark Zone Germinal Center B Cells

Germinal center (GC) B cells surge in their proliferative capacity, which poses a direct risk for B cell malignancies. G1- to S-phase transition is dependent on the expression and stability of D-type cyclins. We show that cyclin D3 expression specifically regulates dark zone (DZ) GC B cell prolifera...

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Detalles Bibliográficos
Autores principales: Ramezani-Rad, Parham, Chen, Cindi, Zhu, Zilu, Rickert, Robert C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7714654/
https://www.ncbi.nlm.nih.gov/pubmed/33207194
http://dx.doi.org/10.1016/j.celrep.2020.108403