Early restoration of parvalbumin interneuron activity prevents memory loss and network hyperexcitability in a mouse model of Alzheimer’s disease

Neuronal network dysfunction is increasingly recognized as an early symptom in Alzheimer’s disease (AD) and may provide new entry points for diagnosis and intervention. Here, we show that amyloid-beta-induced hyperexcitability of hippocampal inhibitory parvalbumin (PV) interneurons importantly contr...

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Detalles Bibliográficos
Autores principales: Hijazi, Sara, Heistek, Tim S., Scheltens, Philip, Neumann, Ulf, Shimshek, Derya R., Mansvelder, Huibert D., Smit, August B., van Kesteren, Ronald E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7714697/
https://www.ncbi.nlm.nih.gov/pubmed/31431685
http://dx.doi.org/10.1038/s41380-019-0483-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7714697/
https://www.ncbi.nlm.nih.gov/pubmed/31431685
http://dx.doi.org/10.1038/s41380-019-0483-4

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