MODL-31. RADIATION-DERIVED TREATMENT-RESISTANT PDX AND CELL CULTURE MODELS RECAPITULATE THE CHARACTERISTICS OF MATCHED PRIMARY/RECURRENT PEDIATRIC HIGH-GRADE GLIOMA

BACKGROUND: Pediatric high-grade glioma (pHGG) is the most common cause of childhood cancer death. Recurrence after therapy is a major challenge, since recurrent pHGG proliferates aggressively and resists therapy. We developed and validated preclinical models of matched primary and recurrent tumors,...

Descripción completa

Detalles Bibliográficos
Autores principales: Knox, Aaron J, Flannery, Patrick, Zukosky, Anjali, DeSisto, John, Sanford, Bridget, van Court, Benjamin, Donson, Andrew, Lemma, Rakeb, Chatwin, Hannah, Karam, Sana D, Vibhakar, Rajeev, Jones, Ken, Green, Adam L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Preclinical Models/Experimental Therapy/Drug Discovery
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715163/
http://dx.doi.org/10.1093/neuonc/noaa222.604

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715163/
http://dx.doi.org/10.1093/neuonc/noaa222.604

Ejemplares similares