EPEN-22. SINGLE-CELL RNA SEQUENCING IDENTIFIES UPREGULATION OF IKZF1 IN PFA2 MYELOID SUBPOPULATION DRIVING AN ANTI-TUMOR PHENOTYPE

We have previously shown immune gene phenotype variations between posterior fossa ependymoma subgroups. PFA1 tumors chronically secrete IL-6, which pushes the infiltrating myeloid cells to an immune suppressive function. In contrast, PFA2 tumors have a more immune activated phenotype and have a bett...

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Detalles Bibliográficos
Autores principales: Griesinger, Andrea, Prince, Eric, Donson, Andrew, Riemondy, Kent, Ritzman, Timothy, Harris, Faith, Amani, Vladimir, Handler, Michael, Hankinson, Todd, Grundy, Richard, Jackson, Andrew, Foreman, Nicholas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Ependymoma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715268/
http://dx.doi.org/10.1093/neuonc/noaa222.159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715268/
http://dx.doi.org/10.1093/neuonc/noaa222.159

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