IMMU-17. CAR T CELLS TARGETING THE INTEGRIN ALPHA(V)BETA(3) EXHIBIT ROBUST ANTI-TUMOR RESPONSES AGAINST DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) AND GLIOBLASTOMA (GBM)

Effective therapies for DIPG and GBM are lacking. CD19 chimeric antigen receptor (CAR) T cells are highly effective in patients with refractory B-cell malignancies. We aim to develop novel CARs for high-grade gliomas. The integrin complex alpha(v)beta(3) was selected as a CAR-T cell target due to it...

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Detalles Bibliográficos
Autores principales: Cobb, Dustin, de Rossi, Jacopo, Liu, Lixia, An, Erin, Lee, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715308/
http://dx.doi.org/10.1093/neuonc/noaa222.373

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715308/
http://dx.doi.org/10.1093/neuonc/noaa222.373

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