THER-08. SGT53 – A NOVEL p53 NANOMEDICINE INDUCES SIGNIFICANT RESPONSES IN CHILDREN WITH RECURRENT MEDULLOBLASTOMA AND CHOROID PLEXUS CARCINOMA: A REPORT OF TWO CASES

BACKGROUND: Abnormal p53 function commonly defines high-risk CNS tumors, but functional restoration has eluded investigators. SGT-53 is a targeted nanomedicine encapsulating a plasmid DNA encoding wild-type human p53 with a transferrin receptor-targeting scFv on the nanocomplex surface resulting in...

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Detalles Bibliográficos
Autores principales: Hwang, Eugene, Kilburn, Lindsay, Hancock, Lauren, Pirollo, Kathleen, Leung, Chris, Packer, Roger, Chang, Esther
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Viral/Gene Therapy and other Novel Therapies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715354/
http://dx.doi.org/10.1093/neuonc/noaa222.858

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715354/
http://dx.doi.org/10.1093/neuonc/noaa222.858

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