DDEL-16. UNDERSTANDING OPTIMAL CONVECTION-ENHANCED DELIVERY PHYSICO-CHEMICAL INFUSION PARAMETERS: THE ROLE OF BBB EFFLUX PUMPS IN DRUG DISTRIBUTION AND CLEARANCE

BACKGROUND: Diffuse midline gliomas harboring the H3K27M mutation are aggressive and universally fatal brain tumors that primarily occur in children. The blood-brain barrier (BBB) prevents many drugs from reaching the tumor at cytotoxic concentrations and efflux pumps found on the epithelial cells o...

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Detalles Bibliográficos
Autores principales: Power, Erica, Zhang, Liang, Daniels, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Drug Delivery/Pharmacokinetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715363/
http://dx.doi.org/10.1093/neuonc/noaa222.051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715363/
http://dx.doi.org/10.1093/neuonc/noaa222.051

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