DIPG-51. ACVR1 MUTATIONS PROMOTE TUMOR GROWTH IN MODELS OF DIFFUSE INTRINSIC PONTINE GLIOMA

Mutations in the gene encoding activin A receptor type 1 (ACVR1) are found in approximately 25% of diffuse intrinsic pontine gliomas (DIPGs), a pediatric glioma with 2-year survival rate of less than 10%. ACVR1mutations frequently coincide with activating PIK3CA or PIK3R1 mutations, indicating a pot...

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Detalles Bibliográficos
Autores principales: Adorno, Jennifer Ocasio, Hover, Laura, He, Chen, Zhu, Xiaoyan, Goldhamer, David, Carcaboso, Angel, Yadavilli, Sridevi, Nazarian, Javad, Baker, Suzanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Diffuse Midline Glioma/DIPG
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715394/
http://dx.doi.org/10.1093/neuonc/noaa222.096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715394/
http://dx.doi.org/10.1093/neuonc/noaa222.096

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