DIPG-29. PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE (PI3K) INHIBITION DRIVES PROTEIN KINASE C ACTIVATION (PKC) IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)

Recurring somatic mutations and gene amplifications to members of the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) signaling axis are overarching contributors to the aggressive growth and survival of diffuse intrinsic pontine gliomas (DIPG). However, targeting PI3K has thus far failed to im...

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Detalles Bibliográficos
Autores principales: Duchatel, Ryan J, Mannan, Abdul, Jackson, Evangeline R, Staudt, Dilana, Skerrett-Byrne, David A, Jamaluddin, M Fairuz B, Woldu, Ameha S, Douglas, Alicia, Hulleman, Esther, Carcaboso, Angel M, Monje, Michelle, Alvaro, Frank, Tsoli, Maria, Ziegler, David S, Dun, Matthew D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Diffuse Midline Glioma/DIPG
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715471/
http://dx.doi.org/10.1093/neuonc/noaa222.078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715471/
http://dx.doi.org/10.1093/neuonc/noaa222.078

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