ATRT-06. SMARCB1 LOSS DRIVEN NON-CANONICAL PRC1 ACTIVITY REGULATES DIFFERENTIATION IN ATYPICAL TERATOID RHABDOID TUMORS (ATRT)

Loss of SMARCB1 is the hallmark genetic event that characterizes ATRT. SMARCB1 is a member of the SWI/SNF chromatin remodeling complex that is responsible for determining cellular pluripotency and lineage commitment. To identify co-operating epigenetic factors, we performed an unbiased shRNA screen...

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Detalles Bibliográficos
Autores principales: Alimova, Irina, Danis, Etienne, Weetall, Marla, Pierce, Angela M, Wang, Dong, Serkova, Natalie, Balakrishnan, Ilango, Madhavan, Krishna, Sanford, Bridget, Michel, Cole, Foreman, Nicholas K, Baird, John, Venkataraman, Sujatha, Vibhakar, Rajeev
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Atypical Teratoid/Rhabdoid Tumors
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715494/
http://dx.doi.org/10.1093/neuonc/noaa222.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715494/
http://dx.doi.org/10.1093/neuonc/noaa222.006

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