IMMU-05. B7-H3-SPECIFIC CAR T CELLS HAVE POTENT ANTI-TUMOR ACTIVITY IN THE GL261 IMMUNE-COMPETENT MURINE BRAIN TUMOR MODEL

BACKGROUND: We and others have identified B7-H3 (CD276) as a promising target for CAR-based immunotherapies for pediatric brain tumors. So far, B7-H3-CAR T cells have only been studied in xenograft models for brain tumors, which do not recapitulate the immunosuppressive tumor microenvironment (TME)....

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Detalles Bibliográficos
Autores principales: Haydar, Dalia, Yi, Zhongzhen, DeRenzo, Chris, Gottschalk, Stephen, Krenciute, Giedre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715514/
http://dx.doi.org/10.1093/neuonc/noaa222.361

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715514/
http://dx.doi.org/10.1093/neuonc/noaa222.361

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