TBIO-16. NOTCH1 PATHWAY AS TARGET FOR DRUG INTERVENTION FOR HISTONE 3 G34R MUTATED pHGG

There have been no significant improvements in the treatments for childhood High-Grade Glioma (pHGG) and Diffuse Intrinsic Pontine Glioblastoma (DIPG), which continue to have a very poor prognosis. These cancers harbor mutations affecting histone 3 (H3) proteins; 80% of DIPGs with histone H3 K27M so...

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Detalles Bibliográficos
Autores principales: Foot, Katie, Lourdusamy, Anbarasu, Christou, Sofia, Rahman, Ruman, Layfield, Robert, Grundy, Richard, Haque, Farhana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Tumor Biology (not fitting a specific disease category)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715737/
http://dx.doi.org/10.1093/neuonc/noaa222.843

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715737/
http://dx.doi.org/10.1093/neuonc/noaa222.843

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