NFB-01. FUNCTIONAL CHARACTERIZATION OF ATRX LOSS IN NF1-ASSOCIATED GLIOMA AND MPNST

To identify the biologic relevance of ATRX loss in NF1-associated gliomagenesis, we studied the effects of Atrx loss using four previously characterized Nf1(+/-)Trp53(+/-) murine glioma lines. Lines 130G#3 and 158D#8 (corresponding to grade IV and III gliomas, respectively) displayed preserved ATRX...

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Detalles Bibliográficos
Autores principales: Yuan, Ming, Reilly, Karlyne, Pratilas, Christine, Heaphy, Christopher, Rodriguez, Fausto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Neurofibromatosis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715779/
http://dx.doi.org/10.1093/neuonc/noaa222.605

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715779/
http://dx.doi.org/10.1093/neuonc/noaa222.605

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