MBRS-33. TEMPORARY RESTORATION OF p53 ACTIVITY DURING FRACTIONATED RADIOTHERAPY IN A GROUP3 MEDULLOBLASTOMA GEMM REPRESENTS A POWERFUL TOOL FOR RADIOBIOLOGY STUDIES

TP53 pathway alterations are well-described events in medulloblastoma (MB) and are predictive of poor clinical outcome. Alterations are rare at diagnosis in Group3 (Gr3) and Group4, but enriched in Sonic Hedgehog and WNT subgroups. However, TP53 mutations are observed in all subgroups at relapse. Ra...

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Detalles Bibliográficos
Autores principales: Morcavallo, Alaide, Mandeville, Henry, Barker, Karen, Richardson, Stacey, Lindsey, Janet, Lockett, Nikita, Boult, Jessica K R, Robinson, Simon P, Oelfke, Uwe, Williamson, Daniel, Clifford, Steven C, Chesler, Louis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Medulloblastoma (Research)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715786/
http://dx.doi.org/10.1093/neuonc/noaa222.547

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715786/
http://dx.doi.org/10.1093/neuonc/noaa222.547

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