TBIO-12. THE SPECTRUM OF MITOCHONDRIAl DNA (mtDNA) MUTATIONS IN PEDIATRIC CENTRAL NERVOUS SYSTEM (CNS) TUMORS

To explore the role of mitochondrial DNA mutations in pediatric CNS tumors, we analyzed 749 tumor-normal paired whole genome sequencing data sets from the Children’s Brain Tumor Tissue Consortium (CBTTC). We detected 307 somatic mtDNA mutations in 222 CNS tumors (29.6%). Most frequently observed wer...

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Detalles Bibliográficos
Autores principales: Kaneva, Kristiyana, Triska, Petr, Merkurjev, Daria, Bootwalla, Moiz, Cotter, Jennifer, Ostrow, Dejerianne, O’Halloran, Katrina, Biegel, Jaclyn, Gai, Xiaowu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Tumor Biology (not fitting a specific disease category)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715789/
http://dx.doi.org/10.1093/neuonc/noaa222.839

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715789/
http://dx.doi.org/10.1093/neuonc/noaa222.839

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