LGG-35. FUNCTIONAL GENOMIC APPROACHES TO IDENTIFY THERAPEUTIC TARGETS IN MYB AND MYBL1 EXPRESSING PEDIATRIC LOW-GRADE GLIOMAS

AIM: Recurrent structural variants involving MYB and MYBL1 transcription factors were recently identified in pediatric low-grade gliomas (pLGGs), such as the MYB-QKI rearrangement in Angiocentric Gliomas and truncations of MYBL1 (MYBL1tr) in Diffuse Astrocytomas. However, therapeutic dependencies in...

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Detalles Bibliográficos
Autores principales: Condurat, Alexandra-Larisa, Wefers, Annika, Gonzalez, Elizabeth, Doshi, Jeyna, Khadka, Prasidda, Jessa, Selin, Tsai, Jessica, Buchan, Graham, Rouleau, Cecile, Abid, Tanaz, Goodale, Amy, Persky, Nicole, Beroukhim, Rameen, Root, David, Ligon, Keith, Jabado, Nada, Kleinman, Clauda L, Piccioni, Federica, Jones, David T W, Bandopadhayay, Pratiti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Low Grade Glioma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715914/
http://dx.doi.org/10.1093/neuonc/noaa222.417

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715914/
http://dx.doi.org/10.1093/neuonc/noaa222.417

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