APOE ε4/ε4 homozygotes with early Alzheimer's disease show accelerated hippocampal atrophy and cortical thinning that correlates with cognitive decline

INTRODUCTION: Hippocampal volume (HV) and cortical thickness are commonly used imaging biomarkers in Alzheimer's disease (AD) trials, and may have utility as selection criteria for enrichment strategies. Atrophy rates of these measures, in the high‐risk apolipoprotein E (APOE) ε4/ε4 homozygous...

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Detalles Bibliográficos
Autores principales: Abushakra, Susan, Porsteinsson, Anton P., Sabbagh, Marwan, Bracoud, Luc, Schaerer, Joel, Power, Aidan, Hey, John A., Scott, David, Suhy, Joyce, Tolar, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7716452/
https://www.ncbi.nlm.nih.gov/pubmed/33304988
http://dx.doi.org/10.1002/trc2.12117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7716452/
https://www.ncbi.nlm.nih.gov/pubmed/33304988
http://dx.doi.org/10.1002/trc2.12117

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