Known Evolutionary Paths Are Accessible to Engineered ß-Lactamases Having Altered Protein Motions at the Timescale of Catalytic Turnover

The evolution of new protein functions is dependent upon inherent biophysical features of proteins. Whereas, it has been shown that changes in protein dynamics can occur in the course of directed molecular evolution trajectories and contribute to new function, it is not known whether varying protein...

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Detalles Bibliográficos
Autores principales: Alejaldre, Lorea, Lemay-St-Denis, Claudèle, Perez Lopez, Carles, Sancho Jodar, Ferran, Guallar, Victor, Pelletier, Joelle N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7716773/
https://www.ncbi.nlm.nih.gov/pubmed/33330628
http://dx.doi.org/10.3389/fmolb.2020.599298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7716773/
https://www.ncbi.nlm.nih.gov/pubmed/33330628
http://dx.doi.org/10.3389/fmolb.2020.599298

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