Presumption of guilt for T cells in type 1 diabetes: lead culprits or partners in crime depending on age of onset?

Available evidence provides arguments both for and against a primary pathogenic role for T cells in human type 1 diabetes. Genetic susceptibility linked to HLA Class II lends strong support. Histopathology documents HLA Class I hyperexpression and islet infiltrates dominated by CD8(+) T cells. While...

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Detalles Bibliográficos
Autores principales: Carré, Alexia, Richardson, Sarah J., Larger, Etienne, Mallone, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717061/
https://www.ncbi.nlm.nih.gov/pubmed/33084970
http://dx.doi.org/10.1007/s00125-020-05298-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717061/
https://www.ncbi.nlm.nih.gov/pubmed/33084970
http://dx.doi.org/10.1007/s00125-020-05298-y

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