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Presumption of guilt for T cells in type 1 diabetes: lead culprits or partners in crime depending on age of onset?
Available evidence provides arguments both for and against a primary pathogenic role for T cells in human type 1 diabetes. Genetic susceptibility linked to HLA Class II lends strong support. Histopathology documents HLA Class I hyperexpression and islet infiltrates dominated by CD8(+) T cells. While...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717061/ https://www.ncbi.nlm.nih.gov/pubmed/33084970 http://dx.doi.org/10.1007/s00125-020-05298-y |