Mechanistic and biological characterisation of novel N(5)-substituted paullones targeting the biosynthesis of trypanothione in Leishmania

Trypanothione synthetase (TryS) produces N(1),N(8)-bis(glutathionyl)spermidine (or trypanothione) at the expense of ATP. Trypanothione is a metabolite unique and essential for survival and drug-resistance of trypanosomatid parasites. In this study, we report the mechanistic and biological characteri...

Descripción completa

Detalles Bibliográficos
Autores principales: Medeiros, Andrea, Benítez, Diego, Korn, Ricarda S., Ferreira, Vinicius C., Barrera, Exequiel, Carrión, Federico, Pritsch, Otto, Pantano, Sergio, Kunick, Conrad, de Oliveira, Camila I., Orban, Oliver C. F., Comini, Marcelo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717452/
https://www.ncbi.nlm.nih.gov/pubmed/32588679
http://dx.doi.org/10.1080/14756366.2020.1780227

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717452/
https://www.ncbi.nlm.nih.gov/pubmed/32588679
http://dx.doi.org/10.1080/14756366.2020.1780227

Ejemplares similares