Echinacoside Suppresses Amyloidogenesis and Modulates F-actin Remodeling by Targeting the ER Stress Sensor PERK in a Mouse Model of Alzheimer’s Disease

Endoplasmic reticulum stress (ERS) plays a vital and pathogenic role in the onset and progression of Alzheimer’s disease (AD). Phosphorylation of PKR-like endoplasmic reticulum kinase (PERK) induced by ERS depresses the interaction between actin-binding protein filamin-A (FLNA) and PERK, which promo...

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Detalles Bibliográficos
Autores principales: Dai, Yuan, Han, Guanghui, Xu, Shijun, Yuan, Yongna, Zhao, Chunyan, Ma, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717986/
https://www.ncbi.nlm.nih.gov/pubmed/33330477
http://dx.doi.org/10.3389/fcell.2020.593659

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717986/
https://www.ncbi.nlm.nih.gov/pubmed/33330477
http://dx.doi.org/10.3389/fcell.2020.593659

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