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Legumain-induced intracerebrally crosslinked vesicles for suppressing efflux transport of Alzheimer's disease multi-drug nanosystem

Brain barrier is both a protective permeability hurdle and a limitation site where therapeutic agents are excluded to enter the target region. Designing drug vehicle to overcome this notorious barrier bottle is challenging. Herein, we construct a stimuli-responsive self-assembled nanovesicle that de...

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Detalles Bibliográficos
Autores principales: Jiang, Fuxin, Ren, Jian, Gao, Yachai, Wang, Jinna, Zhao, Yiping, Dai, Fengying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718144/
https://www.ncbi.nlm.nih.gov/pubmed/33313452
http://dx.doi.org/10.1016/j.bioactmat.2020.11.024