Association of clozapine-related metabolic disturbances with CYP3A4 expression in patients with schizophrenia

Clozapine is effective in treatment-resistant schizophrenia; however, adverse effects often result in discontinuation of clozapine therapy. Many of the side-effects are associated with pharmacokinetic variations; therefore, the expression of major clozapine-metabolizing enzymes (CYP1A2, CYP3A4) in p...

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Detalles Bibliográficos
Autores principales: Menus, Ádám, Kiss, Ádám, Tóth, Katalin, Sirok, Dávid, Déri, Máté, Fekete, Ferenc, Csukly, Gábor, Monostory, Katalin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718230/
https://www.ncbi.nlm.nih.gov/pubmed/33277605
http://dx.doi.org/10.1038/s41598-020-78474-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718230/
https://www.ncbi.nlm.nih.gov/pubmed/33277605
http://dx.doi.org/10.1038/s41598-020-78474-0

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