Discovery of a novel fibroblast activation protein (FAP) inhibitor, BR103354, with anti-diabetic and anti-steatotic effects

Fibroblast growth factor (FGF) 21 is a class of hepatokines that plays a protective role against obesity, insulin resistance, and liver damage. Despite this, protective effects of FGF21 in human appear to be minimal, possibly due to its proteolytic cleavage by the fibroblast activation protein (FAP)...

Descripción completa

Detalles Bibliográficos
Autores principales: Cho, Jae Min, Yang, Eun Hee, Quan, Wenying, Nam, Eun Hye, Cheon, Hyae Gyeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718273/
https://www.ncbi.nlm.nih.gov/pubmed/33277568
http://dx.doi.org/10.1038/s41598-020-77978-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718273/
https://www.ncbi.nlm.nih.gov/pubmed/33277568
http://dx.doi.org/10.1038/s41598-020-77978-z

Ejemplares similares