Epigenetic activation of a RAS/MYC axis in H3.3K27M-driven cancer

Histone H3 lysine 27 (H3K27M) mutations represent the canonical oncohistone, occurring frequently in midline gliomas but also identified in haematopoietic malignancies and carcinomas. H3K27M functions, at least in part, through widespread changes in H3K27 trimethylation but its role in tumour initia...

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Detalles Bibliográficos
Autores principales: Pajovic, Sanja, Siddaway, Robert, Bridge, Taylor, Sheth, Javal, Rakopoulos, Patricia, Kim, Byungjin, Ryall, Scott, Agnihotri, Sameer, Phillips, Lauren, Yu, Man, Li, Christopher, Milos, Scott, Patel, Palak, Srikanthan, Dilakshan, Huang, Annie, Hawkins, Cynthia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718276/
https://www.ncbi.nlm.nih.gov/pubmed/33277484
http://dx.doi.org/10.1038/s41467-020-19972-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718276/
https://www.ncbi.nlm.nih.gov/pubmed/33277484
http://dx.doi.org/10.1038/s41467-020-19972-7

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