Structure, lipid scrambling activity and role in autophagosome formation of ATG9A

De novo formation of the double-membrane compartment autophagosome is seeded by small vesicles carrying membrane protein autophagy-related 9 (ATG9), whose function remains unknown. Here we find that ATG9A scrambles phospholipids of membranes in vitro. Cryo-EM structures of human ATG9A reveal a trime...

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Detalles Bibliográficos
Autores principales: Maeda, Shintaro, Yamamoto, Hayashi, Kinch, Lisa N., Garza, Christina M., Takahashi, Satoru, Otomo, Chinatsu, Grishin, Nick V., Forli, Stefano, Mizushima, Noboru, Otomo, Takanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718406/
https://www.ncbi.nlm.nih.gov/pubmed/33106659
http://dx.doi.org/10.1038/s41594-020-00520-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718406/
https://www.ncbi.nlm.nih.gov/pubmed/33106659
http://dx.doi.org/10.1038/s41594-020-00520-2

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