Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers

An essential protein of the SARS-CoV-2 virus, the envelope protein E, forms a homopentameric cation channel that is important for virus pathogenicity. Here we report a 2.1 Å structure and the drug-binding site of E’s transmembrane domain (ETM), determined using solid-state NMR spectroscopy. In lipid...

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Detalles Bibliográficos
Autores principales: Mandala, Venkata S., McKay, Matthew J., Shcherbakov, Alexander A., Dregni, Aurelio J., Kolocouris, Antonios, Hong, Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718435/
https://www.ncbi.nlm.nih.gov/pubmed/33177698
http://dx.doi.org/10.1038/s41594-020-00536-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718435/
https://www.ncbi.nlm.nih.gov/pubmed/33177698
http://dx.doi.org/10.1038/s41594-020-00536-8

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