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Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers

An essential protein of the SARS-CoV-2 virus, the envelope protein E, forms a homopentameric cation channel that is important for virus pathogenicity. Here we report a 2.1 Å structure and the drug-binding site of E’s transmembrane domain (ETM), determined using solid-state NMR spectroscopy. In lipid...

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Detalles Bibliográficos
Autores principales:	Mandala, Venkata S., McKay, Matthew J., Shcherbakov, Alexander A., Dregni, Aurelio J., Kolocouris, Antonios, Hong, Mei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718435/ https://www.ncbi.nlm.nih.gov/pubmed/33177698 http://dx.doi.org/10.1038/s41594-020-00536-8

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