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Protein synthesis inhibitors stimulate MondoA transcriptional activity by driving an accumulation of glucose 6-phosphate

BACKGROUND: Protein synthesis is regulated by the availability of amino acids, the engagement of growth factor signaling pathways, and adenosine triphosphate (ATP) levels sufficient to support translation. Crosstalk between these inputs is extensive, yet other regulatory mechanisms remain to be char...

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Detalles Bibliográficos
Autores principales: Wilde, Blake R., Kaadige, Mohan R., Guillen, Katrin P., Butterfield, Andrew, Welm, Bryan E., Ayer, Donald E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718662/
https://www.ncbi.nlm.nih.gov/pubmed/33292639
http://dx.doi.org/10.1186/s40170-020-00233-6