A Novel Mapping Strategy Utilizing Mouse Chromosome Substitution Strains Identifies Multiple Epistatic Interactions That Regulate Complex Traits

The genetic contribution of additive vs. non-additive (epistatic) effects in the regulation of complex traits is unclear. While genome-wide association studies typically ignore gene-gene interactions, in part because of the lack of statistical power for detecting them, mouse chromosome substitution...

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Detalles Bibliográficos
Autores principales: Miller, Anna K., Chen, Anlu, Bartlett, Jacquelaine, Wang, Li, Williams, Scott M., Buchner, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2020
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718749/
https://www.ncbi.nlm.nih.gov/pubmed/33023974
http://dx.doi.org/10.1534/g3.120.401824

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718749/
https://www.ncbi.nlm.nih.gov/pubmed/33023974
http://dx.doi.org/10.1534/g3.120.401824

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