Cargando…

Nonlinear mechanics of lamin filaments and the meshwork topology build an emergent nuclear lamina

The nuclear lamina—a meshwork of intermediate filaments termed lamins—is primarily responsible for the mechanical stability of the nucleus in multicellular organisms. However, structural-mechanical characterization of lamin filaments assembled in situ remains elusive. Here, we apply an integrative a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sapra, K. Tanuj, Qin, Zhao, Dubrovsky-Gaupp, Anna, Aebi, Ueli, Müller, Daniel J., Buehler, Markus J., Medalia, Ohad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718915/ https://www.ncbi.nlm.nih.gov/pubmed/33277502 http://dx.doi.org/10.1038/s41467-020-20049-8

Ejemplares similares

Bend, Push, Stretch: Remarkable Structure and Mechanics of Single Intermediate Filaments and Meshworks
por: Sapra, K. Tanuj, et al.
Publicado: (2021)

Filament assembly of the C. elegans lamin in the absence of helix 1A
por: de Leeuw, Rebecca, et al.
Publicado: (2022)

Nuclear lamins: Structure and function in mechanobiology
por: Vahabikashi, Amir, et al.
Publicado: (2022)

Structure and gating of the nuclear pore complex
por: Eibauer, Matthias, et al.
Publicado: (2015)

A laminopathic mutation disrupting lamin filament assembly causes disease-like phenotypes in Caenorhabditis elegans
por: Bank, Erin M., et al.
Publicado: (2011)

Lamin A‐mediated nuclear lamina integrity is required for proper ciliogenesis
por: Fan, Jia‐Rong, et al.
Publicado: (2020)

Stochastic genome-nuclear lamina interactions: Modulating roles of Lamin A and BAF
por: Kind, Jop, et al.
Publicado: (2014)

Tyrosine phosphorylation of lamin A by Src promotes disassembly of nuclear lamina in interphase
por: Chu, Ching-Tung, et al.
Publicado: (2021)

Intermediate filaments: a dynamic network that controls cell mechanics
por: Gruenbaum, Yosef, et al.
Publicado: (2014)

Computational analyses reveal spatial relationships between nuclear pore complexes and specific lamins
por: Kittisopikul, Mark, et al.
Publicado: (2021)

Directed targeting of chromatin to the nuclear lamina is mediated by chromatin state and A-type lamins
por: Harr, Jennifer C., et al.
Publicado: (2015)

Nucleoplasmic lamin C rapidly accumulates at sites of nuclear envelope rupture with BAF and cGAS
por: Kono, Yohei, et al.
Publicado: (2022)

Negative correlation between the nuclear size and nuclear Lamina component Lamin A in intraductal papillary mucinous neoplasms of the pancreas
por: Hiroe, Tamaki, et al.
Publicado: (2022)

Lamin B constitutes an intermediate filament attachment site at the nuclear envelope
Publicado: (1987)

A Correlative Analysis of Actin Filament Assembly, Structure, and Dynamics
por: Steinmetz, Michel O., et al.
Publicado: (1997)

The plant nuclear lamina proteins NMCP1 and NMCP2 form a filamentous network with lateral filament associations
por: Masuda, Kiyoshi, et al.
Publicado: (2021)

The highly conserved nuclear lamin Ig-fold binds to PCNA: its role in DNA replication
por: Shumaker, Dale K., et al.
Publicado: (2008)

Emerin prevents BAF-mediated aggregation of lamin A on chromosomes in telophase to allow nuclear membrane expansion and nuclear lamina formation
por: Snyers, L., et al.
Publicado: (2022)

Pro-fibrotic pathway activation in trabecular meshwork and lamina cribrosa is the main driving force of glaucoma
por: Zhavoronkov, Alex, et al.
Publicado: (2016)

Differential basal-to-apical accessibility of lamin A/C epitopes in the nuclear lamina regulated by changes in cytoskeletal tension
por: Ihalainen, Teemu O., et al.
Publicado: (2015)

Unveiling the polarity of actin filaments by cryo-electron tomography
por: Martins, Bruno, et al.
Publicado: (2021)

The isolation of the nuclear lamina
por: Leslie, Mitch
Publicado: (2005)

Telocytes constitute a widespread interstitial meshwork in the lamina propria and underlying striated muscle of human tongue
por: Rosa, Irene, et al.
Publicado: (2019)

Expression of lamina proteins Lamin and Kugelkern suppresses stem cell proliferation
por: Petrovsky, Roman, et al.
Publicado: (2018)

Cyclin-dependent kinase 1 depolymerizes nuclear lamin filaments by disrupting the head-to-tail interaction of the lamin central rod domain
por: Jeong, Soyeon, et al.
Publicado: (2022)

Mapping the micro-proteome of the nuclear lamina and lamina-associated domains
por: Wong, Xianrong, et al.
Publicado: (2021)

Minimally Invasive Glaucoma Surgery—to Remove or Preserve the Trabecular Meshwork: That is the Question?
por: Dada, Tanuj, et al.
Publicado: (2021)

The nuclear lamina in health and disease
por: Dobrzynska, Agnieszka, et al.
Publicado: (2016)

The intriguing plant nuclear lamina
por: Ciska, Malgorzata, et al.
Publicado: (2014)

A protein antigenically related to nuclear lamin B mediates the association of intermediate filaments with desmosomes
Publicado: (1990)

Structural heterogeneity of cellular K5/K14 filaments as revealed by cryo-electron microscopy
por: Weber, Miriam S, et al.
Publicado: (2021)

Vimentin intermediate filaments and filamentous actin form unexpected interpenetrating networks that redefine the cell cortex
por: Wu, Huayin, et al.
Publicado: (2022)

The Nuclear Pore Complex: Birth, Life, and Death of a Cellular Behemoth
por: Dultz, Elisa, et al.
Publicado: (2022)

Expression and Activity of Collagenases in the Digital Laminae of Horses with Carbohydrate Overload‐Induced Acute Laminitis
por: Wang, L., et al.
Publicado: (2013)

Early cytoplasmic specialization at the presumptive acetylcholine receptor cluster: a meshwork of thin filaments
Publicado: (1984)

Polyphyly of nuclear lamin genes indicates an early eukaryotic origin of the metazoan-type intermediate filament proteins
por: Kollmar, Martin
Publicado: (2015)

Reorganization of the nuclear lamina and cytoskeleton in adipogenesis
por: Verstraeten, Valerie L. R. M., et al.
Publicado: (2011)

Autophagy mediates degradation of nuclear lamina
por: Dou, Zhixun, et al.
Publicado: (2015)

The nuclear lamina during human spermiogenesis
por: Mitchell, Michael
Publicado: (2015)

The Nuclear Lamina as an Organizer of Chromosome Architecture
por: Shevelyov, Yuri Y., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_5q4346pgjg9062kirep0f6hakn