Cargando…

Chloroquine reverses chemoresistance via upregulation of p21(WAF1/CIP1) and autophagy inhibition in ovarian cancer

Overcoming drug-resistance is a big challenge to improve the survival of patients with epithelial ovarian cancer (EOC). In this study, we investigated the effect of chloroquine (CQ) and its combination with cisplatin (CDDP) in drug-resistant EOC cells. We used the three EOC cell lines CDDP-resistant...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hwang, Jae Ryoung, Kim, Woo Young, Cho, Young-Jae, Ryu, Ji-Yoon, Choi, Jung-Joo, Jeong, Soo Young, Kim, Myeong-Sun, Kim, Ji Hye, Paik, E. Sun, Lee, Yoo-Young, Han, Hee-Dong, Lee, Jeong-Won
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718923/ https://www.ncbi.nlm.nih.gov/pubmed/33277461 http://dx.doi.org/10.1038/s41419-020-03242-x

Ejemplares similares

Splicing factor SRSF3 represses translation of p21(cip1/waf1) mRNA
por: Kim, Jeeho, et al.
Publicado: (2022)

Epigenetic Regulation of p21(cip1/waf1) in Human Cancer
por: Ocker, Matthias, et al.
Publicado: (2019)

Expression of p21 (WAF1/CIP1) protein in clinical thyroid tissues.
por: Ito, Y., et al.
Publicado: (1996)

Regenerative Response in Ischemic Brain Restricted by p21(cip1/waf1)
por: Qiu, Jianhua, et al.
Publicado: (2004)

p21(WAF1/CIP1) Expression is Differentially Regulated by Metformin and Rapamycin
por: Molnar, Zoltan, et al.
Publicado: (2014)

TFEB Modulates p21/WAF1/CIP1 during the DNA Damage Response
por: Pisonero-Vaquero, Sandra, et al.
Publicado: (2020)

p21(WAF1/Cip1) Regulation by hYSK1 Activates SP-1 Transcription Factor and Increases MMP-2 Expression under Hypoxic Conditions
por: Lee, Mee-Hyun, et al.
Publicado: (2019)

A New Double Stranded RNA Suppresses Bladder Cancer Development by Upregulating p21(Waf1/CIP1) Expression
por: Wang, Chenghe, et al.
Publicado: (2015)

Loss of p21WAF1/CIP1 expression correlates with disease progression in gastric carcinoma.
por: Ogawa, M., et al.
Publicado: (1997)

TRIM3, a tumor suppressor linked to regulation of p21(Waf1/Cip1)
por: Liu, Yuhui, et al.
Publicado: (2013)

Relationship between Expression of p21(WAF1/CIP1) and Radio resistance in Human Gliomas
por: Kokunai, Takashi, et al.
Publicado: (1999)

p21cip1/waf1 Coordinates Autophagy, Proliferation and Apoptosis in Response to Metabolic Stress
por: Manu, Kanjoormana Aryan, et al.
Publicado: (2019)

Accelerated Aging in Cyclophilin B–Deficient Mice Downstream of p21‐Cip1/Waf1
por: Zhang, Ying, et al.
Publicado: (2022)

YueF Overexpression Inhibits Cell Proliferation Partly through p21(WAF1/Cip1) Upregulation in Renal Cell Carcinoma
por: Huang, Hsuan-Wei, et al.
Publicado: (2011)

p21(WAF1/CIP1) Upregulation through the Stress Granule-Associated Protein CUGBP1 Confers Resistance to Bortezomib-Mediated Apoptosis
por: Gareau, Cristina, et al.
Publicado: (2011)

p21(WAF1/CIP1) RNA Expression in Highly HIV-1 Exposed, Uninfected Individuals
por: Herbeck, Joshua, et al.
Publicado: (2015)

By recruiting HDAC1, MORC2 suppresses p21Waf1/Cip1 in gastric cancer
por: Zhang, Qing, et al.
Publicado: (2015)

The role of p21Waf1/CIP1 as a Cip/Kip type cell-cycle regulator in oral squamous cell carcinoma (Review).
por: Pérez-Sayáns, Mario, et al.
Publicado: (2013)

p53‐independent Induction of p21 (WAF1/CIP1), Reduction of Cyclin B1 and G2/M Arrest by the Isoflavone Genistein in Human Prostate Carcinoma Cells
por: Choi, Yung Hyun, et al.
Publicado: (2000)

Cytoplasmic p21(Cip1/WAF1) regulates neurite remodeling by inhibiting Rho-kinase activity
por: Tanaka, Hiroyuki, et al.
Publicado: (2002)

p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6
por: Phalke, Sameer, et al.
Publicado: (2012)

Protective roles of cytoplasmic p21(Cip1) (/Waf1) in senolysis and ferroptosis of lung cancer cells
por: Koyanagi, Akira, et al.
Publicado: (2022)

p21(CIP/WAF1) saRNA inhibits proliferative vitreoretinopathy in a rabbit model
por: Zhang, Qi, et al.
Publicado: (2023)

Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21(WAF1/CIP1) expression
por: Ho, Dong Hwan, et al.
Publicado: (2015)

Function of p21 (Cip1/Waf1/CDKN1A) in Migration and Invasion of Cancer and Trophoblastic Cells
por: Kreis, Nina-Naomi, et al.
Publicado: (2019)

The Multifaceted p21 (Cip1/Waf1/CDKN1A) in Cell Differentiation, Migration and Cancer Therapy
por: Kreis, Nina-Naomi, et al.
Publicado: (2019)

MiR-224 promotes the chemoresistance of human lung adenocarcinoma cells to cisplatin via regulating G(1)/S transition and apoptosis by targeting p21(WAF1/CIP1)
por: Wang, H, et al.
Publicado: (2014)

MiR-224 promotes the chemoresistance of human lung adenocarcinoma cells to cisplatin via regulating G1/S transition and apoptosis by targeting p21WAF1/CIP1
por: Wang, H, et al.
Publicado: (2014)

Topographic expression of p21WAF1/SDI1/CIP1, bcl2, and p53 is altered at the early stage of colorectal carcinogenesis.
por: Cho, J. H., et al.
Publicado: (2000)

Unique induction of p21(WAF1/CIP1)expression by vinorelbine in androgen-independent prostate cancer cells
por: Liu, X M, et al.
Publicado: (2003)

A human ribonuclease induces apoptosis associated with p21(WAF1/CIP1 )induction and JNK inactivation
por: Castro, Jessica, et al.
Publicado: (2011)

EBV-positive Hodgkin lymphoma is associated with suppression of p21(cip1/waf1 )and a worse prognosis
por: Liu, Ting-Yun, et al.
Publicado: (2010)

p300 Alters Keratinocyte Cell Growth and Differentiation through Regulation of p21(Waf1/CIP1)
por: Wong, Ping-Pui, et al.
Publicado: (2010)

Expression of p21(waf‐1/cip‐1) Is Significantly Induced in the Livers of LEC Rats with Chronic Liver Injury
por: Sawada, Norimasa, et al.
Publicado: (1996)

Lack of Evidence of Association of p21(WAF1/CIP1) Polymorphism with Lung Cancer Susceptibility and Prognosis in Taiwan
por: Shih, Chuen‐Ming, et al.
Publicado: (2000)

Correction to: Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21(WAF1/CIP1) expression
por: Ho, Dong Hwan, et al.
Publicado: (2017)

p21WAF1 Is Required for Interleukin-16-Induced Migration and Invasion of Vascular Smooth Muscle Cells via the p38MAPK/Sp-1/MMP-9 Pathway
por: Park, Sung Lyea, et al.
Publicado: (2015)

Overexpression of FOXG1 contributes to TGF-β resistance through inhibition of p21(WAF1/CIP1) expression in ovarian cancer
por: Chan, D W, et al.
Publicado: (2009)

Multiple polymorphisms, but no mutations, in the WAF1/CIP1 gene in human brain tumours.
por: Koopmann, J., et al.
Publicado: (1995)

DNA-PK(CS) binding to p53 on the p21(WAF1/CIP1) promoter blocks transcription resulting in cell death
por: Hill, Richard, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_i3890rno3ttejva3nvh4oor3tj