TRAP1 enhances Warburg metabolism through modulation of PFK1 expression/activity and favors resistance to EGFR inhibitors in human colorectal carcinomas

Metabolic rewiring is a mechanism of adaptation to unfavorable environmental conditions and tumor progression. TRAP1 is an HSP90 molecular chaperone upregulated in human colorectal carcinomas (CRCs) and responsible for downregulation of oxidative phosphorylation (OXPHOS) and adaptation to metabolic...

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Detalles Bibliográficos
Autores principales: Maddalena, Francesca, Condelli, Valentina, Matassa, Danilo Swann, Pacelli, Consiglia, Scrima, Rosella, Lettini, Giacomo, Li Bergolis, Valeria, Pietrafesa, Michele, Crispo, Fabiana, Piscazzi, Annamaria, Storto, Giovanni, Capitanio, Nazzareno, Esposito, Franca, Landriscina, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718945/
https://www.ncbi.nlm.nih.gov/pubmed/33025742
http://dx.doi.org/10.1002/1878-0261.12814

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718945/
https://www.ncbi.nlm.nih.gov/pubmed/33025742
http://dx.doi.org/10.1002/1878-0261.12814

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