Positioning of an unprecedented spiro[5.5]undeca ring system into kinase inhibitor space

In-house 1,5-oxaza spiroquinone 1, with spiro[5.5]undeca ring system, was announced as an unprecedented anti-inflammatory scaffold through chemistry-oriented synthesis (ChOS), a chemocentric approach. Herein, we studied how to best position the spiro[5.5]undeca ring system in kinase inhibitor space....

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Detalles Bibliográficos
Autores principales: Venkanna, Arramshetti, Subedi, Lalita, Teli, Mahesh K., Lama, Prema Dhorma, Nangunuri, Bhargav Gupta, Lee, Sang-Yoon, Kim, Sun Yeou, Kim, Mi-hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719162/
https://www.ncbi.nlm.nih.gov/pubmed/33277542
http://dx.doi.org/10.1038/s41598-020-78158-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719162/
https://www.ncbi.nlm.nih.gov/pubmed/33277542
http://dx.doi.org/10.1038/s41598-020-78158-9

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