Exploring the Allosteric Mechanism of Src Homology-2 Domain-Containing Protein Tyrosine Phosphatase 2 (SHP2) by Molecular Dynamics Simulations

The Src homology-2 (SH2) domain-containing protein tyrosine phosphatase 2 (SHP2, encoded by PTPN11) is a critical allosteric phosphatase for many signaling pathways. Programmed cell death 1 (PD-1) could be phosphorylated at its immunoreceptor tyrosine-based inhibitory motif (ITIM) and immunoreceptor...

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Detalles Bibliográficos
Autores principales: Wang, Quan, Zhao, Wen-Cheng, Fu, Xue-Qi, Zheng, Qing-Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719740/
https://www.ncbi.nlm.nih.gov/pubmed/33330386
http://dx.doi.org/10.3389/fchem.2020.597495

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719740/
https://www.ncbi.nlm.nih.gov/pubmed/33330386
http://dx.doi.org/10.3389/fchem.2020.597495

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