Paxilline Prevents the Onset of Myotonic Stiffness in Pharmacologically Induced Myotonia: A Preclinical Investigation

Reduced Cl(−) conductance causes inhibited muscle relaxation after forceful voluntary contraction due to muscle membrane hyperexcitability. This represents the pathomechanism of myotonia congenita. Due to the prevailing data suggesting that an increased potassium level is a main contributor, we stud...

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Detalles Bibliográficos
Autores principales: Hoppe, Kerstin, Sartorius, Tina, Chaiklieng, Sunisa, Wietzorrek, Georg, Ruth, Peter, Jurkat-Rott, Karin, Wearing, Scott, Lehmann-Horn, Frank, Klingler, Werner
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719791/
https://www.ncbi.nlm.nih.gov/pubmed/33329012
http://dx.doi.org/10.3389/fphys.2020.533946

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719791/
https://www.ncbi.nlm.nih.gov/pubmed/33329012
http://dx.doi.org/10.3389/fphys.2020.533946

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