Structural Insights on Tiny Peptide Nucleic Acid (PNA) Analogues of miRNA-34a: An in silico and Experimental Integrated Approach

In the present work, structural features of the interaction between peptide nucleic acid (PNA)-based analogs of the tumor-suppressor microRNA-34a with both its binding sites on MYCN mRNA were investigated. In particular, the region from base 1 to 8 (“seed” region) of miR-34a was reproduced in the fo...

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Detalles Bibliográficos
Autores principales: Moccia, Maria, Mercurio, Flavia Anna, Langella, Emma, Piacenti, Valerio, Leone, Marilisa, Adamo, Mauro F. A., Saviano, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719796/
https://www.ncbi.nlm.nih.gov/pubmed/33330358
http://dx.doi.org/10.3389/fchem.2020.568575

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719796/
https://www.ncbi.nlm.nih.gov/pubmed/33330358
http://dx.doi.org/10.3389/fchem.2020.568575

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