A Conserved TCRβ Signature Dominates a Highly Polyclonal T-Cell Expansion During the Acute Phase of a Murine Malaria Infection

CD4(+) αβ T-cells are key mediators of the immune response to a first Plasmodium infection, undergoing extensive activation and splenic expansion during the acute phase of an infection. However, the clonality and clonal composition of this expansion has not previously been described. Using a compara...

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Detalles Bibliográficos
Autores principales: Smith, Natasha L., Nahrendorf, Wiebke, Sutherland, Catherine, Mooney, Jason P., Thompson, Joanne, Spence, Philip J., Cowan, Graeme J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719809/
https://www.ncbi.nlm.nih.gov/pubmed/33329568
http://dx.doi.org/10.3389/fimmu.2020.587756

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719809/
https://www.ncbi.nlm.nih.gov/pubmed/33329568
http://dx.doi.org/10.3389/fimmu.2020.587756

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