Poly (A) tail length of human mitochondrial mRNAs is tissue-specific and a mutation in LRPPRC results in transcript-specific patterns of deadenylation

Mutations in LRPPRC cause Leigh Syndrome French Canadian (LSFC), an early onset neurodegenerative disease, with differential tissue involvement. The molecular basis for tissue specificity in this disease remains unknown. LRPPRC, an RNA binding protein, forms a stable complex with SLIRP, which binds...

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Detalles Bibliográficos
Autores principales: Honarmand, Shamisa, Shoubridge, Eric A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719955/
https://www.ncbi.nlm.nih.gov/pubmed/33312877
http://dx.doi.org/10.1016/j.ymgmr.2020.100687

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719955/
https://www.ncbi.nlm.nih.gov/pubmed/33312877
http://dx.doi.org/10.1016/j.ymgmr.2020.100687

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