Tight and specific lanthanide binding in a de novo TIM barrel with a large internal cavity designed by symmetric domain fusion

De novo protein design has succeeded in generating a large variety of globular proteins, but the construction of protein scaffolds with cavities that could accommodate large signaling molecules, cofactors, and substrates remains an outstanding challenge. The long, often flexible loops that form such...

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Detalles Bibliográficos
Autores principales: Caldwell, Shane J., Haydon, Ian C., Piperidou, Nikoletta, Huang, Po-Ssu, Bick, Matthew J., Sjöström, H. Sebastian, Hilvert, Donald, Baker, David, Zeymer, Cathleen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7720202/
https://www.ncbi.nlm.nih.gov/pubmed/33203677
http://dx.doi.org/10.1073/pnas.2008535117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7720202/
https://www.ncbi.nlm.nih.gov/pubmed/33203677
http://dx.doi.org/10.1073/pnas.2008535117

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