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Overlapping-sample Mendelian randomisation with multiple exposures: a Bayesian approach

BACKGROUND: Mendelian randomization (MR) has been widely applied to causal inference in medical research. It uses genetic variants as instrumental variables (IVs) to investigate putative causal relationship between an exposure and an outcome. Traditional MR methods have mainly focussed on a two-samp...

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Detalles Bibliográficos
Autores principales: Zou, Linyi, Guo, Hui, Berzuini, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7720408/
https://www.ncbi.nlm.nih.gov/pubmed/33287714
http://dx.doi.org/10.1186/s12874-020-01170-0