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Mitophagy promotes sorafenib resistance through hypoxia-inducible ATAD3A dependent Axis
BACKGROUND: The identification of novel targets for recovering sorafenib resistance is pivotal for Hepatocellular carcinoma (HCC) patients. Mitophagy is the programmed degradation of mitochondria, and is likely involved in drug resistance of cancer cells. Here, we identified hyperactivated mitophagy...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7720487/ https://www.ncbi.nlm.nih.gov/pubmed/33280610 http://dx.doi.org/10.1186/s13046-020-01768-8 |