Characterization of Stable and Reactive Metabolites of the Anticancer Drug, Ensartinib, in Human Liver Microsomes Using LC-MS/MS: An in silico and Practical Bioactivation Approach

BACKGROUND: Ensartinib (ESB) is a novel anaplastic lymphoma kinase inhibitor (ALK) with additional activity against Abelson murine leukemia (ABL), met proto-oncogene (MET), receptor tyrosine kinase (AXL), and v-ros UR2 sarcoma virus oncogene homolog 1 (ROS1) and is considered a safer alternative for...

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Detalles Bibliográficos
Autores principales: Abdelhameed, Ali S, Attwa, Mohamed W, Kadi, Adnan A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721118/
https://www.ncbi.nlm.nih.gov/pubmed/33299299
http://dx.doi.org/10.2147/DDDT.S274018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721118/
https://www.ncbi.nlm.nih.gov/pubmed/33299299
http://dx.doi.org/10.2147/DDDT.S274018

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